What is Chemical Genomics?
Chemical genomics is the study of small molecule interactions within cells. It is used for large-scale protein analysis and experimental research into drug therapies as it provides a good method for studying gene and protein functions in a model.
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Chemical Genomics in a Mouse Model
Using a mouse model, an invitro chemical screen can be performed to identify small molecules that may rescue the phenotypes of ABCA12 mutant mice. This would involve taking skin punches from the mice and preparing cell cultures. Then a diverse chemical library would be applied to look for positive hits of molecules that appear to rescue phenotypes such as abnormal lamellar granule formation.
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Discussion
There are not many studies that have been done connecting chemical genomics and the ABCA12 gene, but by conducting the screen above, there could potentially result in identifying a target for future drug therapies.
This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison