What are protein interaction networks?
Protein-to-protein interaction networks are models of how proteins physically contact one another in cells, and outline their biological functions. Through examining protein network interactions one can better understand the physical and functional interactions of proteins, as well as their signaling pathway. Proteins can be further sorted by gene ontology to group them with proteins of similar function.
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Discussion
Above are the human and mouse protein interaction networks for the ABCA12 gene. Proteins involved in skin barrier development, epidermis development, and lipid transport can all be seen having interactions with ABCA12 in humans. Similar protein interaction groups are observed in mice, suggesting that ABCA12 is strongly linked to proper skin formation.
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This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison