What are Protein Domains?
Protein domains are a conserved set of amino acids that are structurally or functionally distinct to a specific protein [1]. Because protein domains function independently, identifying domains is useful for protein classification and for understanding a protein's function.
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What Domains are Present in ABCA12?
Conserved Domains of ABCA12
Here we see conserved domains found by homology sequencing across different model organism. In both the human genome and the model organisms genomes, the ABCA12 membrane and transport domains are present twice.
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Discussion
In the model organisms above, the presence of both the ABC2 membrane domain and the ABC transport domain across, as well as the similarities in amino acid length show the high conservation of the ABCA12 gene in the genomes of multiple organisms.
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This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison
References:
[1]. Family and domain based protein classification. Retrieved from https://www.ebi.ac.uk/training/online/course/introduction-protein-classification-ebi/protein-classification/family-and-domain-based-protei |
Image References:
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